RESUMO
El interferón alfa se utiliza para tratar y controlar la evolución de diversas enfermedades, destacando como terapia de elección de la hepatitis crónica por virus hepatitis C. Dentro de sus efectos secundarios ha sido asociado a la producción de síntomas depresivos llegando incluso a ser una contraindicación para su uso el hecho de estar cursando con un episodio depresivo en el presente. Se describe un caso de un síndrome depresivo activo en un paciente con hepatitis crónica por virus hepatitis C, con indicación de tratamiento con interferón alfa
Interferon alpha is used to treat and control several diseases nowadays being a primary component of treatment for chronic hepatitis C. It has been associated to the development of side effects, in particular the occurrence of depressive symptoms, which could be a contraindication for its administration if the patient is experiencing depression in the present. We present the case of a patient with chronic hepatitis C and depressive syndrome, with indication for interferon alpha therapy
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Depressão , Hepatite C , Hepatite Crônica , Interferon-alfa , Unidade Hospitalar de PsiquiatriaRESUMO
El TDAH fue descrito hace casi 150 años, definido actualmente por el DSM-IV como un determinado grado de déficit de atención y/o hiperactividad-impulsividad que resulta desadaptativo en relación con el nivel de desarrollo del niño. Está asociado a gran discapacidad y alta comorbilidad psiquiátrica, por lo que se ha convertido en uno de los trastornos psiquiátricos infantiles más estudiados. En el presente artículo se revisa cómo ha ido evolucionando el concepto de TDAH desde una perspectiva histórica, evolucionista y neuropsiquiátrica, mencionando las principales hipótesis, estudios y aportes de la ciencia que han influido en su mejor comprensión. Se revisarán los temas más relevantes en relación al desarrollo del DSM-V y cómo éste debería replantearse de acuerdo a los nuevos hallazgos y a la literatura publicada a la fecha.
ADHD was first described almost 150 years ago, defined in the DSM-IV as a disruptive behavior disorder characterized by the presence of impairing behavior patterns that display abnormal levels of inattention, hyperactivity and impulsivity. It has been associated to important discapacity and psychiatric comorbidity, becoming one of the most studied child psychiatric disorders. We review how the concept of ADHD has evolved, from an historic, evolutionary and neuropsychiatric point of view, mentioning the mayor scientific hypothesis, studies and findings that have influenced its better understanding. In addition we review literature available about the most relevant item related to the development of DSM-V, and discuss about how the diagnosis should be reformulated according to these new findings and current available literature.
Assuntos
Humanos , Adulto , Criança , Manual Diagnóstico e Estatístico de Transtornos Mentais , Transtorno do Deficit de Atenção com Hiperatividade/diagnóstico , Idade de Início , Evolução Biológica , Endofenótipos , Meio Ambiente , Neurobiologia , Transtorno do Deficit de Atenção com Hiperatividade/epidemiologia , Transtorno do Deficit de Atenção com Hiperatividade/genética , Transtorno do Deficit de Atenção com Hiperatividade/terapiaRESUMO
An acute left ventricular disfunction, induced by physical or emotional stress, has been described, known as Tako-tsubo syndrome. Acute coronary disease has shown to be its most important differential diagnosis, based on the similar clinical findings described in this group of patients. It usually presents with chest pain, reversible ST segment elevation in the electrocardiogram, discrete myocardial enzyme elevation and transient left ventricular wall motion abnormality, with no significant coronary arteries disease demonstrated. In this article we present the case of a46 year old woman with a typical Tako-tsubos syndrome medical profile who was hospitalized in our Hospital, with an initial diagnosis of an acute ST elevation myocardial infarction. We describe the general study and management of this syndrome and make a discussion about the subject.
